Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds to phosphorylated target proteins. SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling. SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE; the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. Ubiquitination of NFKBIA occurs at 'Lys-21' and 'Lys-22'. SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB1/nuclear factor NF-kappa-B p105 subunit, ATF4, SMAD3, SMAD4, CDC25A, DLG1, FBXO5 and probably NFKB2. SCF(BTRC) mediates the ubiquitination of phosphorylated SNAI1. May be involved in ubiquitination and subsequent proteasomal degradation through a DBB1-CUL4 E3 ubiquitin-protein ligase. Required for activation of NFKB-mediated transcription by IL1B, MAP3K14, MAP3K1, IKBKB and TNF. Required for proteolytic processing of GLI3.
chain F-box/WD repeat-containing protein 1A 1 605 domain F-box 190 228 repeat WD 1 301 338 repeat WD 2 341 378 repeat WD 3 381 418 repeat WD 4 424 461 repeat WD 5 464 503 repeat WD 6 505 541 repeat WD 7 553 590 region of interest Homodimerization domain D 128 177 region of interest Required for down-regulation of SNAI1 190 228 splice variant In isoform 2. 17 52 sequence variant In dbSNP:rs4151060. 543 sequence variant In dbSNP:rs2270439. 592