TagContent
UUCD ID
UUC-HoS-00457 
Organism
Homo sapiens
Source
Classification
Group/FamilyScoreE-ValueStartEndDomain length
E3 adaptor/Cullin RING/DCX/DWD19.30.00531532915
E3 adaptor/Cullin RING/SCF/F-box51.82.1e-1313818649
UniProt
Protein Name
F-box/WD repeat-containing protein 1A 
Protein Synonyms/Alias
E3RSIkappaB; F-box and WD repeats protein beta-TrCP; pIkappaBalpha-E3 receptor subunit 
Gene Name
BTRC 
Gene Synonyms/Alias
BTRCP; FBW1A; FBXW1A 
Ensembl
Gene Position
10:103113820-103317078 
Orientation
forward 
Transcripts
Orthologs
SpeciesUUCD ID
Ailuropoda melanoleucaUUC-AiM-00905
Anolis carolinensisUUC-AnC-00247
Bos taurusUUC-BoT-00584
Caenorhabditis elegansUUC-CaE-00025
Callithrix jacchusUUC-CaJ-00490
Canis familiarisUUC-CaF-00303
Cavia porcellusUUC-CaP-00254
Ciona intestinalisUUC-CiI-00537
Dipodomys ordiiUUC-DiO-00432
Drosophila melanogasterUUC-DrM-00031
Echinops telfairiUUC-EcT-00459
Equus caballusUUC-EqC-00228
Erinaceus europaeusUUC-ErE-00383
Gallus gallusUUC-GaG-00641
Gorilla gorillaUUC-GoG-00207
Loxodonta africanaUUC-LoA-00591
Macaca mulattaUUC-MaM-00879
Macropus eugeniiUUC-MaE-00420
Meleagris gallopavoUUC-MeG-00468
Monodelphis domesticaUUC-MoD-00662
Mus musculusUUC-MuM-00020
Myotis lucifugusUUC-MyL-00248
Nomascus leucogenysUUC-NoL-00744
Ochotona princepsUUC-OcP-00422
Oryctolagus cuniculusUUC-OrC-00560
Otolemur garnettiiUUC-OtG-00580
Pan troglodytesUUC-PaT-00947
Petromyzon marinusUUC-PeM-00271
Pongo abeliiUUC-PoA-00943
Procavia capensisUUC-PrC-00424
Pteropus vampyrusUUC-PtV-00505
Rattus norvegicusUUC-RaN-00004
Sarcophilus harrisiiUUC-SaH-00507
Schizosaccharomyces pombeUUC-ScP-00041
Sorex araneusUUC-SoA-00352
Spermophilus tridecemlineatusUUC-SpT-00344
Sus scrofaUUC-SuS-00452
Taeniopygia guttataUUC-TaG-00529
Tarsius syrichtaUUC-TaS-00343
Tupaia belangeriUUC-TuB-00403
Tursiops truncatusUUC-TuT-00504
Vicugna pacosUUC-ViP-00324
Xenopus tropicalisUUC-XeT-00447
Protein Length
564 AA 
Protein Sequence
MCSMPRSLWL GCSSLADSMP SLRCLYNPGT GALTAFQTYN SCARLCLNQE TVCLASTAMK 60
TENCVAKTKL ANGTSSMIVP KQRKLSASYE KEKELCVKYF EQWSESDQVE FVEHLISQMC 120
HYQHGHINSY LKPMLQRDFI TALPARGLDH IAENILSYLD AKSLCAAELV CKEWYRVTSD 180
GMLWKKLIER MVRTDSLWRG LAERRGWGQY LFKNKPPDGN APPNSFYRAL YPKIIQDIET 240
IESNWRCGRH SLQRIHCRSE TSKGVYCLQY DDQKIVSGLR DNTIKIWDKN TLECKRILTG 300
HTGSVLCLQY DERVIITGSS DSTVRVWDVN TGEMLNTLIH HCEAVLHLRF NNGMMVTCSK 360
DRSIAVWDMA SPTDITLRRV LVGHRAAVNV VDFDDKYIVS ASGDRTIKVW NTSTCEFVRT 420
LNGHKRGIAC LQYRDRLVVS GSSDNTIRLW DIECGACLRV LEGHEELVRC IRFDNKRIVS 480
GAYDGKIKVW DLVAALDPRA PAGTLCLRTL VEHSGRVFRL QFDEFQIVSS SHDDTILIWD 540
FLNDPAAQAE PPRSPSRTYT YISR 564 
Domain Profile

DWD: 315-329aa

S: 2     LatgsaDsrvklWDv  16

         ++tgs+Ds+v++WDv

Q: 315   IITGSSDSTVRVWDV  329

         68************8

F-box: 138-186aa

S: 1     dslskLP....eeiLleILsrLdsardLlacalVCkrWrellrddsllwkk  47

         d+++ LP    ++i ++ILs+Ld a++L+a+ lVCk W+++++d  +lwkk

Q: 138   DFITALParglDHIAENILSYLD-AKSLCAAELVCKEWYRVTSDG-MLWKK  186

         68999*****************9.9*****************999.66665

Domain Sequence
>DWD
IITGSSDSTV RVWDV 15 
>F-box
DFITALPARG LDHIAENILS YLDAKSLCAA ELVCKEWYRV TSDGMLWKK 49 
Theoretical PI
8.30 
Molecular Weight
68866.79 
Genbank Protein ID
Genbank Nucleotide ID
NCBI Taxa ID
9606
Functional Description
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds to phosphorylated target proteins. SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling. SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE; the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. Ubiquitination of NFKBIA occurs at 'Lys-21' and 'Lys-22'. SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB1/nuclear factor NF-kappa-B p105 subunit, ATF4, SMAD3, SMAD4, CDC25A, DLG1, FBXO5 and probably NFKB2. SCF(BTRC) mediates the ubiquitination of phosphorylated SNAI1. May be involved in ubiquitination and subsequent proteasomal degradation through a DBB1-CUL4 E3 ubiquitin-protein ligase. Required for activation of NFKB-mediated transcription by IL1B, MAP3K14, MAP3K1, IKBKB and TNF. Required for proteolytic processing of GLI3. 
Sequence Annotation
chain F-box/WD repeat-containing protein 1A 1 605
domain F-box 190 228
repeat WD 1 301 338
repeat WD 2 341 378
repeat WD 3 381 418
repeat WD 4 424 461
repeat WD 5 464 503
repeat WD 6 505 541
repeat WD 7 553 590
region of interest Homodimerization domain D 128 177
region of interest Required for down-regulation of SNAI1 190 228
splice variant In isoform 2. 17 52
sequence variant In dbSNP:rs4151060. 543
sequence variant In dbSNP:rs2270439. 592
Keyword
3D-structure,Alternative splicing,Complete proteome,Cytoplasm,Host-virus interaction,Ligase,Nucleus,Polymorphism,Reference proteome,Repeat,Ubl conjugation pathway,WD repeat,Wnt signaling pathway 
Sequence Source
UniProt 
Gene Ontology
GO:0005829; C:cytosol; TAS:Reactome
GO:0005634; C:nucleus; IEA:UniProtKB-SubCell
GO:0019005; C:SCF ubiquitin ligase complex; IDA:UniProtKB
GO:0046983; F:protein dimerization activity; IEA:InterPro
GO:0031145; P:anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; TAS:Reactome
GO:0044419; P:interspecies interaction between organisms; IEA:UniProtKB-KW
GO:0043433; P:negative regulation of sequence-specific DNA binding transcription factor activity; TAS:BHF-UCL
GO:0045879; P:negative regulation of smoothened signaling pathway; TAS:BHF-UCL
GO:0045892; P:negative regulation of transcription, DNA-dependent; IMP:UniProtKB
GO:0045862; P:positive regulation of proteolysis; IMP:UniProtKB
GO:0051437; P:positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; TAS:Reactome
GO:0031648; P:protein destabilization; IMP:UniProtKB
GO:0016032; P:viral reproduction; TAS:Reactome
GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW 
KEGG
InterPro
InterPro; IPR021977; Beta-TrCP_D
InterPro; IPR001810; F-box_dom_cyclin-like
InterPro; IPR020472; G-protein_beta_WD-40_rep
InterPro; IPR015943; WD40/YVTN_repeat-like_dom
InterPro; IPR001680; WD40_repeat
InterPro; IPR019775; WD40_repeat_CS
InterPro; IPR017986; WD40_repeat_dom
Pfam
Pfam; PF12125; Beta-TrCP_D
Pfam; PF00400; WD40 
SMART
SMART; SM01028; Beta-TrCP_D
SMART; SM00256; FBOX
SMART; SM00320; WD40